Impact of obesity on leptin, leptin receptor gene polymorphism, and some adipokines in egyptian patients with knee osteoarthritis
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منابع مشابه
Impact of Leptin Receptor Gene GLN223ARG Polymorphism on Obesity in Jeddah City
Obesity is a major global epidemic problem. Obesity results from the combined effects of genes, environment, lifestyle and the interactions of these factors. The leptin receptor gene plays a critical role in the regulation of body weight. Genetic variations of leptin receptor gene may play a role in the pathophysiology of human obesity. In this study, the association between the LepR gene polym...
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Objective(s):Leptin receptor (LEPR) is a member of the class I cytokine receptor super-family that is known implicated in the initiation and progression of breast cancer. We have investigated the effect of Q223R polymorphism on the breast cancer susceptibly in a sample of Iranian subjects. Materials and Methods:We utilized a polymerase chain reaction (PCR) restriction fragment length polymorphi...
متن کاملLeptin receptor gene polymorphisms and morbid obesity in Mexican patients
BACKGROUND Human obesity is due to a complex interaction among environmental, behavioral, developmental and genetic factors, including the interaction of leptin (LEP) and leptin receptor (LEPR). Several LEPR mutations and polymorphisms have been described in patients with early onset severe obesity and hyperphagic eating behavior; however, some contradictory findings have also been reported. In...
متن کاملLeptin, soluble leptin receptor and leptin gene polymorphism in relation to preeclampsia risk.
Few investigators have simultaneously evaluated leptin, soluble leptin receptor (SLR) and leptin gene polymorphisms in preeclampsia cases and controls. We examined these three biomolecular markers in 40 preeclampsia cases and 39 controls. Plasma leptin and SLR concentrations were determined using immunoassays. Genotype for the tetranucleotide repeat (TTTC)(n), polymorphism in the 3 -flanking re...
متن کاملAssociation of leptin gene (rs 7799039) polymorphism and colorectal cancer
Introduction: Studies show polymorphism in leptin gene cause increase in level of leptin hormone and increased level of leptin hormon is associated with abosity, insulin resistance and increased risk of colorectal cancer. The aim of this study was to assess the incidence of leptin gene polymorphism rs 7799039 in Tehran and to investigate the influence of this polymorphism in increased risk of c...
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ژورنال
عنوان ژورنال: Indian Journal of Rheumatology
سال: 2020
ISSN: 0973-3698
DOI: 10.4103/injr.injr_71_19